HSD17B6 antibody

Catalog No. ABIN7115154

This anti-HSD17B6 antibody is a Rabbit Polyclonal antibody detecting HSD17B6 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for HSD17B6 antibody (ABIN7115154)

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-HSD17B6 Antibody

Purpose: HSD17B6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: hydroxysteroid(17-beta) dehydrogenase 6 homolog(Mouse)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for HSD17B6

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Alternative Name: HSD17B6

Background:

Synonyms: 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6, 17-beta-HSD6)|3-alpha->beta-hydroxysteroid epimerase (3-alpha->beta-HSE)|Oxidative 3-alpha hydroxysteroid dehydrogenase|Short chain dehydrogenase/reductase family 9C member 6|HSD17B6|RODH|SDR9C6

Background: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity(in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids(in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone(in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone(in vitro). Has retinol dehydrogenase activity towards all-trans-retinol(in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

Molecular Weight: 33-35 kDa

Gene ID: 8630

UniProt: O14756

Pathways: Steroid Hormone Biosynthesis